Technology Description: UC San Diego researchers have invented a deletion mutant of a Streptomyces spp. bacterium intended to facilitate the design and creation of new compounds with anti-bacterial, anti-fungal, anti-cancer, or other bioactive properties. These strains have had more of their genetic content deleted than the existing art, providing more utility for metabolic engineering activities and synthetic biology. One would insert plasmids, BACs, etc., that contain genes and pathways encoding for the production of a bioactive compound of interest into this strain. Alternatively, one could integrate these genes and/or pathways directly into the chromosome, if desired.
Keywords: platform strain, novel compound design, anti-bacterial, anti-infective
Case Number: SD2011-034
Inquiries To: invent@ucsd.edu
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