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This invention teaches a novel new class of pyrone, thiopyrone and hydroxypyrindinone derivatives as metal chelators; these compounds can be potent and selective inhibitors for metalloprotein, MMPs and anthrax lethal factor.
Current art describes substitution at the 2 or 4 position, these compounds have substitutions at the 5 position. This set of derivatives has not yet been described in the literature.
To date, the inventors have developed a synthetic route, target compounds have been developed and are being tested as metal chelators.
From a commercial standpoint, these new compounds hold promise as therapeutic agents (for cancer, anthrax, heart disease, arthritis, and others) or as diagnostic agents (for medical imaging).
Case No: SD2007-058
Inquiries To: invent@ucsd.edu
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