Although algorithms and chemistries for developing new therapeutic entities are constantly evolving, none can replicate the path and novelty of natural selection over eons of time.  Inventors at the Scripps Institution of Oceanography have engaged their fleet of research ships to cull the oceans for marine organisms from which new compositions are isolated.  Using a variety of culture systems, selective fractionation and bioassays, two, distinct classes of compounds, isolated from actinomycetes, have demonstrated potent anti-tumor activity and considerable selectivity toward some cancers.  One class of compounds, the ammosamides, are unique molecules that target a previously untargeted intracellular pathway.  It is anticipated that proprietary methods and naturally evolved compositions may yield therapeutics that are significantly differentiated from those developed by limited iteration of pre-defined platforms.

Related Research and Information is found at:
http://scrippsnews.ucsd.edu/Releases/?releaseID=719
http://fenical.ucsd.edu/Fenical%20Home.htm

Patents pending

Case No: 2006-079 & 2003-248  

Keywords:chemical entity, chemical entities, composition, marine, tumor, composition

Inquiries To:  invent@ucsd.edu