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UCSD inventors have used several polyamine ligands as "warheads" which result in compounds that are more selective for copper and zinc. The ability of the compounds to bind metals in the active site of a protein or enzyme will make these effective inhibitors. It is anticipated that the compounds will be potent inhibitors with fewer side effects than seen with hydroxamic acids.
Some synthetic chemistry and limited biological activity assays (several of the compounds have already been tested in vitro and show activity against MMPs and/or lethal factor) have been done. No animal work has been done yet.
The potential of these compounds remain to be determined, but it is anticipated that they could be useful as biotechnology research tools, therapeutic agents for diseases such as anthrax, heart disease, cancer, arthritis, stroke, etc.
Case No: SD2006-069
Keywords: shock, inflammatory disease
Inquiries To: invent@ucsd.edu
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