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The immune response plays a critical role in protecting humans and animals from infection and the development of tumors. Compositions that increase the immune response (adjuvants) are therefore valuable for improving vaccine efficacy and the control of tumor growth and metastasis.
Novel combinations of molecules that are immunostimulatory have been discovered. Certain of these adjuvants have been used to treat a variety of tumor types in mouse models and the results demonstrate dramatic reductions in tumor size and increased survival rates. Additionally, a combination of the molecules has been tested as an adjuvant for an anti-infective vaccine and has produced improved protective effects.
This technology is simple, inexpensive and has broad potential utility for improving existing vaccines against a variety of microbial infections and for improving immunotherapeutic approaches for treating cancer.
Case No: SD2005-252
Inquiries To: invent@ucsd.edu
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