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Background:
UCSD researchers have discovered that a certain gene encoding a glycosyltransferase is able to regulate levels of glucose transporters on pancreatic beta cells. Over-expression of this gene in mice promoted glucose transporter activity on the plasma membrane, increasing glucose uptake and insulin secretion. When the expression of this gene was impaired, the mice developed type II diabetes.
Invention:
This invention provides methods to treat diabetes by controlling the expression of a gene encoding a glycosyltransferase. This glycosyltransferase might also be a promising target for cancer, since the increase in glucose transport resulting from this enzyme's activity contributes to the high metabolic rates found in cancer cells.
Case No: SD2004-243
Inquiries To: invent@ucsd.edu
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