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UCSD researchers have determined a novel activity for a family of small c-terminal domain phosphatases (SCP) in regulating gene transcription by preferentially dephosphorylating ser5 of RNA polymerase II. The UCSD researchers have developed methods for upregulating or downregulating gene expression by modulating the activity of the SCP enzymes. The invention has applications as a platform for drug discovery, in diagnosing cancer or neurological disease, and in research reagent development.
CASE NUMBER: SD2003-061
Inquiries To: invent@ucsd.edu
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