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The Equalizer is a custom application which uses rank-order
similarity in gene expression intensity to construct
non-linear "equalization vectors which are then
used to linerize the data matrix to a consistent slope
of 1. In addition, The Equalizer rationally eliminates
"negative" values of expression seen in Affymetrix
data. Use of The Equalizer greatly facilitates downstream
data analysis.
This software has been used for Affymetrix chip analysis
but has applications to other microarray systems as
well (see Robert O. Stuart, Kevin T. Bush, and Sanjay
K. Nigam. 2001. Changes in global gene expression patterns
during development and maturation of the rat kidney.
PNAS. 98:5649-54).
Visit Web Site: http://organogenesis.ucsd.edu/software.html
for more information.
CASE NUMBER: SD2001-814
INQUIRIES TO: invent@ucsd.edu
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