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An ambitious goal of proteomics is to elucidate the
structure, interactions and functions of all proteins
within cells and organisms. The expectation is that
this will provide a fuller appreciation of cellular
processes and networks at the protein level, ultimately
leading to a better understanding of disease mechanisms
and suggesting new means for intervention. This technology
provides a means to predict protein-protein interactions
directly from primary structure and associated data.
The system consistently predicts protein interactions
at an accuracy rate above 80%.
The methodology may have applications in cell-map proteomics,
genetic regulatory circuits modeling, epitope discovery,
target-based drug design, cellular signaling and in
blood-contacting biomaterials design. Future proteomics
studies may benefit from this technology by proceeding
directly from the automated identification of a cell's
gene products to prediction of protein interaction pairs.
CASE NUMBER: SD2001-034
INQUIRES TO: invent@ucsd.edu
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