The goal of Insilicomed is to provide computational bioengineering software tools to medical technology companies to avoid ineffective and expensive prototyping, optimize product design, shorten product development cycles, and reduce R&D costs. Concurrently, Insilicomed is developing clinical simulation tools to provide clinical decision support to cardiologists for the diagnosis and treatment of heart failure and other forms of heart disease.

Through computational models, Insilicomed’s software and databases integrate biological science, medical knowledge, and engineering principles. Insilicomed provides innovative predictive simulation tools and detailed biological properties in a form suitable for engineers to perform quantitative analyses for rapidly testing new medical technology concepts and designs. The company’s current platform technology simulates the physical properties of human cardiovascular tissue, including heart muscle and blood vessels, and the human eye, including cornea, sclera and optic nerve. Existing modules of the software are designed for use by medical device manufacturers during the R&D phase of new or improved cardiovascular and ocular products. Future modules will expand the use of this platform technology to medical imaging, surgical planning, clinical decision support, and other fields that would benefit from computational modeling of biological tissues and systems.
Insilicomed’s initial target is cardiovascular device design because of the expertise of its founders in the analysis of heart disease and the credible successes to date of its technology as a tool in the development of cardiovascular devices and therapies. Large and small medical technology companies have already benefited from these tools.

The company can provide engineering support services for medical device design, development and testing. For example, device-tissue interactions are typically complex and require accurate models of both the device and the tissue, in addition to the interactions between the two. Such modeling analyses are the specialty of Insilicomed.

The cardiovascular modeling specialists and engineering support staff at Insilicomed can perform mechanical analyses on a wide variety of devices and tissues and their interactions. Mechanical loads on implanted devices and their effects on the surrounding tissue depend critically on the accuracy of the model parameters. Modeling these interactions with realistic input parameters and appropriate computational methods is the benefit of using Insilicomed’s services. Predictive analyses for cardiovascular-device systems can be performed, including fatigue and failure analysis, stress and strain estimates in tissues and devices, tissue reactions to implanted devices, and organ function.



Computational model of the left and right ventricles, showing a view of the basal valve plane. This model was based on experimental measurements in the pig. Changes in properties of the heart with disease, for example arrhythmias, heart failure and ischemic heart disease, can be incorporated into these computational models to examine functional changes in a diseased state.




7825 Fay Ave, Suite 200, La Jolla, CA 92037
Tel: (619) 501-8894
Founded: 2002

Lewis Waldman, PhD – CEO, Co-founder and Board Member,
Jeff Omens, PhD – Co-founder, Board Member, and Professor of Medicine and Bioengineering


Technology Innovator:


Andrew McCulloch, PhD
Chair, Scientific Advisory Board
Professor and former Chair, Department of Bioengineering
Jacobs School of Engineering